ABSTRACT
The comparative bioavailabilities (bioequivalence) of five generic brands of paracetamol were compared in six (6) healthy male volunteers. The aim was to study whether the generic brands are bioequivalent to the standard brand. The study was carried out following oral administration of 1g of each brand after wash-out period of two weeks. The concentration of paracetamol in the saliva samples were determined using UV – spectrophotometer. The pharmacokinetic parameters for bioavailability evaluation Cmax, Tmax and AUC were determined. The values of reference tablet panadol® was Cmax 48.50 ± 21.82 µg/ml, Tmax 1 ± 0.41 (hr), AUC 238.13 ± 12.4 µg/ml/hr, while test brand XA was Cmax31.50 ± 16.83 µg/ml, Tmax 0.5 ± 0.25 (hr), AUC 117.93 ± 8.10µg/ml/hr, XB Cmax50.0±17.39µg/ml, Tmax0.50 ±0.25 (hr), AUC 202.0 ± 12.56 µg/ml/hr, XC Cmax42.0 ± 17.39µg/ml, Tmax1 ± 0.41 (hr), AUC 192.63 ± 10.07µg/ml/hr, XD Cmax50.0 ± 15.82µg/ml, Tmax1±0.41 (hr), AUC 256.13 ±11.51µg/ml/hr and XE Cmax5.3 ± 2.4 µg/ml, Tmax3±1.07 (hr), AUC 27.03 ± 1.34 µg/ml/hr. Reference ratio of three generic brands XB, XC and XD were bioequivalent to the standard brand because their limits lies within the bioequivalent range of 0.8 – 1.25 or 80% - 125% confidence limits with panadol® while the other two brands XA and XE were not within these bioequivalence range with panadol® .
BACKGROUND OF STUDY
In the majority of underdeveloped nations, including Nigeria, maternal mortality is th...
ABSTRACT Climate change is having a tremendous effect on our fragile ecosystem where the acceleration of its effect is believed to have occurred as...
ABSTRACT
The effect of stock control in an organization is so vital in both large and small firm whether in the publ...
BACKGROUND OF THE STUDY
In the world today, transportation which is the conveyance of goods and passeng...
Abstract
This study interrogates the participation of private security companies in crime control in Ni...
ABSTRACT
The focus of this study is to examine the effectiveness of internal control system and it’s i...
Background Of The Study
The putative "coronavirus" is thought to be a zoonotic virus that cau...
ABSTRACT
Performance Management processes have become prominent in recent years as means of providing a more integrated and continuous ap...
ABSTRACT
Corrupt practices among Female Civil Servants (FCS) seem to be increasing despite the establishment of Anti-Corruption and Trans...
ABSTRACT
Inflation is one of the macroeconomic problems facing many developing countries today and Nigeria is not exempt...